Pyridine carboxylic acids as inhibitors and substrates of the Escherichia coli gab permease encoded by gabP.
نویسندگان
چکیده
Although considered selective for its natural substrate, 4-aminobutyrate, gab permease was inhibited by 1,2,3,6-tetrahydro-3-pyridinecarboxylate and 1,2,3,6-tetrahydro-4-pyridinecarboxylate. The former is a transported substrate, since its preloading into metabolically poisoned cells stimulated transient accumulation of 4-aminobutyrate via counterflow.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 177 18 شماره
صفحات -
تاریخ انتشار 1995